Abstract

JURADO, Leonardo F et al. Pathological and molecular diagnosis in a case of primary laryngeal tuberculosis in a physician. Biomédica [online]. 2014, vol.34, n.1, pp.15-20. ISSN 0120-4157.  https://doi.org/10.7705/biomedica.v34i1.1624.

Primary laryngeal tuberculosis is a rare disease with a wide variety of clinical manifestations. We report the case of an ear-nose and throat diabetic physician with primary laryngeal tuberculosis. The diagnosis of laryngeal cancer had been considered before in another institution, and at the patient´s admission, he only presented dysphonia with a six-month evolution. The vocal cord histological examination showed granulomas, giant cells, fibrosis and necrosis, and the Ziehl-Neelsen staining showed acid-alcohol resistant bacilli. The culture from vocal cord tissue was positive for mycobacteria, and IS 6110 -PCR was positive too. The Mycobacterium tuberculosis strain was sensitive to first line drugs. Treatment using directly observed therapy short-course (DOTS) was initiated. Clinical presentation, differential diagnosis, diagnostic workup, associated risk factors and a brief literature revision are discussed in this article.

Keywords : Mycobacterium tuberculosis; polymerase chain reaction; laryngeal tuberculosis; granuloma; dysphonia.

        · abstract in Spanish     · text in Spanish     · Spanish ( pdf )