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Biomédica
Print version ISSN 0120-4157
Abstract
MOLINA-SOTOMAYOR, Edgardo et al. Effects of exercise on the cognition of older women treated with lovastatin. Biomédica [online]. 2018, vol.38, n.4, pp.496-506. ISSN 0120-4157. https://doi.org/10.7705/biomedica.v38i4.4262.
Introduction:
The deterioration of cognition is highly predominant in older adults.
Objective:
The aim of this study was to analyze the effects of a walking program on the cognition and blood concentration of lipids in women over 60 years of age who were being treated with lovastatin.
Materials and methods:
Participants were distributed in two groups: An exercise group (EG, n=45) with aerobic training and an inactive sedentary group (SG, n=22). The cognitive state of the subjects was assessed through the Spanish Mini-Cog Test version of the MMSE; lipoproteins were quantified using a lipid profile test, and the cardiorespiratory fitness was measured using the six-minute walking test (6MWT).
Results:
EG showed a significant increase (p<0.05) in cardiorespiratory fitness and in HDL-C concentrations. Furthermore, the results from the cognition tests showed a large effect size in spatial orientation and in and calculation. The decrease in LDL-C was not significant (p>0.05).
Conclusion:
A controlled and progressive walking program for older women treated with Lovastatin may induce a boost of brain activity linked to HDL-C, which could delay cognitive impairment.
Keywords : Exercise; cognition; dyslipidemia; hydroxymethylglutaryl-CoA reductase inhibitors; mental health; aging.