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Biomédica
Print version ISSN 0120-4157
Abstract
VARGAS-RESTREPO, Felipe; SABOGAL-GUAQUETA, Angélica María and CARDONA-GOMEZ, Gloria Patricia. Quercetin ameliorates inflammation in CA1 hippocampal region in aged triple transgenic Alzheimer´s disease mice model. Biomédica [online]. 2018, vol.38, suppl.1, pp.62-69. ISSN 0120-4157. https://doi.org/10.7705/biomedica.v38i0.3761.
Introduction:
Alzheimer’s disease is the most common form of dementia. It is characterized by histopathological hallmarks such as senile plaques and neurofibrillary tangles, as well as a concomitant activation of microglial cells and astrocytes that release pro-inflammatory mediators such as IL-1β, iNOS, and COX-2, leading to neuronal dysfunction and death.
Objective:
To evaluate the effect of quercetin on the inflammatory response in the CA1 area of the hippocampus in a 3xTg-AD male and female mice model.
Materials and methods:
Animals were injected intraperitoneally with quercetin every 48 hours during three months, and we conducted histological and biochemical studies.
Results:
We found that in quercetin-treated 3xTg-AD mice, reactive microglia and fluorescence intensity of Aβ aggregates significantly decreased. GFAP, iNOS, and COX-2 immunoreactivity also decreased and we observed a clear tendency in the reduction of IL-1β in hippocampal lysates.
Conclusion:
Our work suggests an anti-inflammatory effect of quercetin in the CA1 hippocampal region of aged triple transgenic Alzheimer’s disease mice.
Keywords : Alzheimer disease; quercetin; microglia; astrocytes.