Services on Demand
Journal
Article
Indicators
Cited by SciELO
Access statistics
Related links
Cited by Google
Similars in SciELO
Similars in Google
Share
Avances en Psicología Latinoamericana
Print version ISSN 1794-4724On-line version ISSN 2145-4515
Abstract
MACHADO DIAS, Álvaro and LUIZ RODRIGUES, E Avelino. Schizophrenia, genetics, epigenesis, environment: a systematic review of unified etiological hypotheses and genetic profile; and a new algorithm to cope with the main findings. Av. Psicol. Latinoam. [online]. 2010, vol.28, n.1, pp.29-41. ISSN 1794-4724.
Context: schizophrenia is a highly complex syndrome, related to genes, and to non-genetic risk factors. Famous epidemiological studies reported its presence among all cultures and geographic regions. In that sense, Unified Etiological hypothesis face the challenge to both present experimental data, and to show that the findings may cope with the syndromes universal profile. Objectives: systematically review the most prominent Unified Etiological hypothesis, as much as the semantic distribution of genetic findings (under up to date data mining techniques), and propose a new model, based on the dynamic effects of epigenics over genetic activation in both neurodevelopment and early adulthood. Results: in general, Unified Etiological Hypothesis contradict the main genetic findings (which suggest that schizophrenias genes are mostly associated with neurotransmitter profiles, like D-1 and the Glutamate-NMDA cascade); also in general, genetic findings are spread all over the genome (as we reveal with a topological map of the 3519 studies on the matter). The key for this conundrum may be represented by the association between the perspective that each polymorphism associated with schizophrenia represents a statistical risk factor (e.g. increasing the risk of developmental instability) while epigenetic molecular cascades and environmental factors considerably influence this picture, affecting genetic activation within critical periods.
Keywords : schizophrenia; etiology; brain.