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CES Odontología
Print version ISSN 0120-971X
Abstract
GALLEGO-MOLINA, Beatriz Helena et al. Salivary composition and function in children with non-syndromic cl w/wo p. CES odontol. [online]. 2021, vol.34, n.2, pp.61-75. Epub Mar 28, 2022. ISSN 0120-971X. https://doi.org/10.21615/cesodon.5923.
Introduction and objective:
Saliva plays an important role in oral homeostasis, although it is not routinely evaluated in patients with CL±P. This study aimed to compare these characteristics in children with non-syndromic CL±P vs. children without this craniofacial difference.
Materials and methods:
This descriptive study included 17 children with non-syndromic CL±P from Fundación Clínica Noel and 25 children without CL±P. Stimulated (SS) and non-stimulated saliva (NSS) from both groups were collected for physicochemical tests, quantification of ions (Ca, Mg and P), total protein and streptococcus mutans count.
Results:
There were statistically significant differences in pH of SS and NSS, as well as in total protein concentration and buffer capacity in NSS. The pH (p = 0.002) and buffering capacity (p = 0.023) of NSS of CL±P children decreased, while total protein concentration (p = 0.003) increased compared to the control group. A higher streptococcus mutans count was found in NSS of CL±P children (6.39x104 CFU UFC mL-1) compared to the control group (2.21x104 UFC mL-1), although without detecting statistically significant differences (p = 0.243).
Conclusions:
These findings suggest an alteration in the function and composition of NSS in patients with non-syndromic CL±P; which could possibly be explained from the genetic/biological point of view by an alteration in the salivary glands formation and function in these individuals that requires further investigation.
Keywords : cleft lip with or without cleft palate; saliva; composition; salivary function.