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Iatreia
Print version ISSN 0121-0793
Abstract
MEDINA-PATERNINA, Olga; VILLA-DELGADO, Rosmery and GARCIA-BERMEJO, Roberto. The diagnostic challenge of Cushing’s disease in pediatrics: cases report. Iatreia [online]. 2022, vol.35, n.4, pp.466-474. Epub May 26, 2023. ISSN 0121-0793. https://doi.org/10.17533/udea.iatreia.175.
Introduction:
Cushing’s disease (CD) should always be suspected in a pediatric patient with growth delay, excessive weight gain and characteristic phenotype. It is suggested to start a diagnostic protocol sequence: verification of hypercortisolism, production site and images, to finally perform the definitive curative surgical treatment.
Case reports:
We report three CD patients with altered growth velocity, weight gain and characteristic phenotype. The diagnostic sequence was performed to demonstrate hypercortisolism. CD was subsequently confirmed, and a pituitary nuclear magnetic resonance (NMR) was performed. All patients underwent curative surgery.
Conclusion:
CD in pediatrics continues to be a diagnostic challenge for the clinician. An approach with high initial clinical suspicion, associated with paraclinical studies and obtaining the adequate images, are necessary to make an accurate diagnosis and a definitive curative treatment.
Keywords : Cushing syndrome; Hypercortisolism; Magnetic Resonance Imaging.