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Revista científica
Print version ISSN 0124-2253On-line version ISSN 2344-8350
Abstract
TRILLERAS, Jorge; DE-LA-ROTTA, Freddy-Ríos and PEDROZA-GARCIA, Luis-Felipe. Ultrasound-Assisted Synthesis of Fused Polycyclic pyrazolo[3,4-b]pyridines. Rev. Cient. [online]. 2023, n.47, pp.1-12. Epub Sep 20, 2023. ISSN 0124-2253. https://doi.org/10.14483/23448350.19651.
This work describes a synthetic methodology developed to obtain fused polycyclic pyrazolo[3,4-b]pyridines. The synthesis was carried out in two stages, starting with the preparation of α,β-unsaturated naphthones and their subsequent cyclocondensation with 5-amino-1-phenyl-3-methyl-1H-pyrazole. The advantages of this approach include simplicity, atomic efficiency, selectivity, and good yields with minimal environmental impact. The synthetic route is aimed at obtaining N-heterocycles with specific points of structural diversification that are of interest for later exploration of their biological properties.
Keywords : 5-aminopyrazole; cyclocondensation; fused pyrazole derivatives; pyrazolo[3,4-b]pyridine; ultrasound synthesis..