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Revista Colombiana de Psiquiatría
Print version ISSN 0034-7450
Abstract
REVILLA-ZUNIGA, Joshep; CARPIO, Joise Cornejo-Del and CRUZADO, Lizardo. Hepatoxicity Induced by Clozapine: Case Report and Brief Review. rev.colomb.psiquiatr. [online]. 2023, vol.52, n.2, pp.165-170. Epub Aug 15, 2023. ISSN 0034-7450. https://doi.org/10.1016/j.rcp.2021.04.010.
Introduction:
Antipsychotics are drugs that can produce transient elevations of hepatic enzymes. Clozapine is an atypical antipsychotic used in treatment-resistant schizophrenia and there is evidence that it can produce elevations of hepatic transaminases, expression of liver damage in a hepatocellular pattern.
Methods:
Case report and non-systematic review of the relevant literature.
Case presentation:
A 39-year-old woman with a diagnosis of paranoid schizophrenia attended the emergency department of a general hospital for nausea, vomiting and jaundice that appeared after the initiation of clozapine. There was no clinical improvement during hospitalization, and death occurred after 44 days.
Literature review:
Clozapine can increase the liver enzyme levels transiently and asymptomatically; however, there are clinical criteria that recommend the withdrawal of the antipsychotic.
Conclusions:
This is the third case reported in the literature of a fatal outcome of clozapine-induced hepatotoxicity.
Keywords : Drug-induced liver disease; Antipsychotic agents; Adverse event.