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Colombian Journal of Anestesiology
Print version ISSN 0120-3347
Abstract
MACHADO-ALBA, Jorge Enrique; SANCHEZ-MORALES, Leidy Viviana and RODRIGUEZ-RAMIREZ, Luisa Fernanda. Dipyrone-related granulocytopenia. Case report. Rev. colomb. anestesiol. [online]. 2018, vol.46, n.4, pp.327-330. ISSN 0120-3347. https://doi.org/10.1097/cj9.0000000000000053.
Introduction:
Dipyrone has been positioned in several countries as one of the first over-the-counter options for pain management. Its possible adverse effects are known worldwide; among them, agranulocytosis is the most lethal, with a mortality of approximately 10% and an associated risk of 1 per 1,000,000 patients.
Clinical findings, interventions, and outcomes:
A case of a patient who, after 23 days of using dipyrone for pain management, developed a progressive drop in leukocyte count. Other potential causes of the event were ruled out. After dipyrone discontinuation, leukocyte counts returned to their normal values.
Conclusion:
The probable diagnosis of granulocytopenia as a dipyrone-related adverse drug reaction was established. Although rare, dipyrone-related granulocytopenia, may occur in patients who use this medication for long periods.
Keywords : Dipyrone; Agranulocytosis; Pharmacovigilance; Adverse effects; Case Report.