Services on Demand
Journal
Article
Indicators
Cited by SciELO
Access statistics
Related links
Cited by Google
Similars in SciELO
Similars in Google
Share
Revista colombiana de Gastroenterología
Print version ISSN 0120-9957On-line version ISSN 2500-7440
Abstract
OLIVEROS, Ricardo and GRUPO DE PATOLOGIA et al. Evaluación de la concentración sérica de pepsinógeno como método de tamizaje para gastritis atrófica y cáncer gástrico. Rev Col Gastroenterol [online]. 2003, vol.18, n.2, pp.73-77. ISSN 0120-9957.
Gastric cancer has become a health problem in Colombia, because of its very high incidence and late diagnosis. Only 5% of all gastric cancers reported are diagnosed at an early stage. For these reasons a sensitive, adequated cost-effectiveness and with compliance screening program is required. In Japan the I and II pepsinogen tests have proved to be more effective than the fluoroscopic method for the detection of gastric cancer, the rate of detection being of 0.168% vs the 0.066% obtained fluoroscopically. Based on this evidence, we decided to evaluate the use of the pepsinogen tests in two groups as follows: 66 gastric cancer patients and 110 members of the general population. From all of them we obtained blood samples for testing PEP I and H. pylori antibodies, followed by endoscopy and biopsies. We defined the best cut-off point for PEP I using a ROC curve and found that < 150ng/ml was the best cut-off point with sensitivity of 84.3% and specificity of 71.3%. Thus we concluded that PEP I is a good method for detecting chronic atrophic gastritis and gastric cancer, but also due to the high H. pylori infection prevalence (97%) found the PEP II test must be performed in our population.
Keywords : Screening; pepsinogen; atrophic gastritis; gastric cancer.