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Revista colombiana de Gastroenterología
Print version ISSN 0120-9957On-line version ISSN 2500-7440
Abstract
VARGAS-RODRIGUEZ, Ledmar Jovanny et al. Severity Markers of Acute Appendicitis: Diagnostic Test Study. Rev. colomb. Gastroenterol. [online]. 2022, vol.37, n.1, pp.3-9. Epub May 22, 2022. ISSN 0120-9957. https://doi.org/10.22516/25007440.538.
Introduction:
Acute appendicitis (AA) is one of the most frequent abdominal surgical pathologies globally, with appendectomy being the most performed emergency surgery.
Aim:
To determine potential markers of AA severity for diagnostic purposes and timely management, thus avoiding possible complications.
Materials and methods:
This research relies on a randomized sample of 239 patients diagnosed with AA at the Orinoquía Regional Hospital, Colombia. We analyzed blood count, C-reactive protein (CRP), and neutrophil/lymphocyte ratio (NLR) records and established their relationship with the AA surgical findings described by Guzmán-Valdivia.
Results:
In the emergency department, these reactants can provide an approximate diagnosis as markers of the AA severity, with CRP > 15 mg/dL (diagnostic accuracy of 76.15 %) and NLR > 85 % (diagnostic accuracy of 61.09 %) having the best initial operating performance. Regarding complications such as intestinal perforation, we found a statistical relationship; CRP > 15 mg/dL and NLR > 85 % were the markers with the highest predictive performance, with OR 14.46 and OR 2. 17, respectively, regarding Guzmán-Valdivia’s findings.
Conclusions:
CRP and NLR > 85 % are the acute phase reactants with the best diagnostic characteristics to predict potential AA complications.
Keywords : Appendicitis; perforation; biomarkers; severity.