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Revista colombiana de Gastroenterología
Print version ISSN 0120-9957On-line version ISSN 2500-7440
Abstract
MANGRICH,, Ana Carolina de Souza et al. Characteristics and Factors Associated with Inflammatory Activity on Liver Biopsy in Autoimmune Hepatitis Patients Aged 50 Years or Older. Rev. colomb. Gastroenterol. [online]. 2023, vol.38, n.2, pp.173-179. Epub Sep 06, 2023. ISSN 0120-9957. https://doi.org/10.22516/25007440.1022.
Introduction:
Autoimmune hepatitis is a liver inflammatory disorder characterized by portal lymphoplasmacytic hepatitis with interface activity and lobular inflammation.
Objective:
The objective of this study is to identify clinical features associated with advanced age and significant inflammation in liver histology.
Methods:
This cross-sectional analytical study evaluated the medical records of adult patients with hepatitis who received treatment in the gastroenterology and hepatology ward of a tertiary university hospital. Bivariate analysis was conducted to identify characteristics associated with an age of 50 years or older and significant histological inflammatory activity.
Results:
A total of 47 patients were included, with a mean age of 42.8 ± 16.0 (43.0) years. Among them, 80.9% were women, and 31.9% were 50 years or older. Liver biopsy was performed on 31 patients, and 29.0% exhibited significant inflammation. When comparing age groups, individuals aged 50 years and older had a higher median γ-glutamyl transferase (GGT; 129 vs. 282 U/L; p = 0.034) and a higher proportion of significant inflammation (50% vs. 6.7%; p = 0.024). Patients with significant inflammation on liver biopsy had a higher mean age (63.7 ± 14.0 vs. 41.0 ± 14.4; p = 0.001) and a higher proportion of patients aged 50 years or older (85.7% vs. 66.7%; p = 0.024) compared to those with mild inflammation.
Conclusions:
Individuals aged 50 years and older exhibited a higher median GGT and a greater proportion of significant inflammation in liver histology.
Keywords : Autoimmune hepatitis; inflammation; γ-glutamyl transferase; aging.