Abstract

JIMENEZ QUICENO, Judy Natalia  and  CORREA OCHOA, Margarita María. Methycillin-resistant Staphylococcus aureus: molecular bases of resistance; epidemiology, and typification. Iatreia [online]. 2009, vol.22, n.2, pp.147-158. ISSN 0121-0793.

Staphylococcus aureus is responsible for a wide variety of clinical manifestations ranging from skin and soft tissue infections to severe systemic and life threatening diseases; it is of relevance in the community and is commonly associated with nosocomial infections. Additionally, a high percentage of the population is colonized by S. aureus, which constitutes a risk factor for its dissemination. S. aureus has great capacity to acquire antimicrobial resistance, and currently there are resistant strains to the majority of available antibiotics; in particular, its resistance to methycillin, initially in the hospital environment (Hospital associated methycillin resistant S. aureus, HA-MRSA) and later in the community (Community acquired methycillin resistant S. aureus, CA-MRSA), has made even more difficult the worldwide control of this microorganism. Molecular epidemiological studies have provided a better understanding of the evolutionary relationships of the strains, and the definition of the clonal source during epidemic outbreaks. In Colombia, very little is known about S. aureus epidemiology and even less about its behavior in the community. Therefore, studies based on epidemiological surveillance, involving molecular typing, will lead to a better understanding of its epidemiology, making it possible the design of more assertive control strategies.

Keywords : CA- MRSA; HA-MRSA; Methicillin resistance; Molecular epidemiology; Molecular typing; Staphylococcus aureus.