Abstract

USUGA-USUGA, Franky; GARCIA, Luis F.  and  VELASQUEZ-LOPERA, Margarita. COVID-19: a perspective focus on IL-17/Th17. Iatreia [online]. 2022, vol.35, n.1, pp.57-64.  Epub Apr 27, 2022. ISSN 0121-0793.  https://doi.org/10.17533/udea.iatreia.110.

Interleukin 17 (IL-17)-producing helper T cells (Th17) and IL-17 play an important role in the defense against extracellular bacteria and fungi; however, persistent secretion of IL-17 is also an important component in the pathogenesis of many inflammatory and autoimmune diseases. Recent evidence suggests that Th17 cells and IL-17 are also involved in the immunopathogenesis of COVID-19. This review summarizes the evidence related with the role of Th17/IL-17 in severe COVID-19, which support the possible use of IL-17/IL-17R inhibitors in the treatment of this infection.

Keywords : Betacoronavirus; COVID-19; Inflammation; Interleukin-17; Therapy.

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