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Revista Med
Print version ISSN 0121-5256
Abstract
RODRIGUEZ, JAVIER et al. FRACTALS: DIAGNOSTIC HELP FOR PRENEOPLASTIC AND CANCERIGINAL CELLS OF CERVICAL SCALPAL EPITHELIUM CONFIRMATION OF CLINICAL APPLICABILITY. rev.fac.med [online]. 2016, vol.24, n.1, pp.79-88. ISSN 0121-5256. https://doi.org/10.18359/rmed.2334.
Introduction: A new fractal diagnostic method was applied for assessing cervix cells using the Intrinsic Mathematical Harmony (IMH) concept and cellular variability, which mathematically differentiates normal, L-SIL and H-SIL cells making unnecessary the diagnostic of ASCUS cells. Objective: To confirm the diagnostic capability of developed methodology by a blind study of comparison with Gold Standard. Methods: Digital pictures were taken of 50 cells from cytology of 20 to 55 year-old women; 5 with normal diagnosis and 45 with several lesion degrees until carcinoma, including 5 with ASCUS diagnosis. Fractal dimension of three mathematical objects was calculated by superposing five grids: nucleus, cytoplasm and totality. Moreover, their fractal dimension was assessed through the Intrinsic Mathematical Harmony concept and cellular variability. The obtained diagnosis was compared with conventional cytopathologic diagnosis determining sensibility, specificity and Kappa coefficient. Results: 100% Sensibility and specificity, and a Kappa Coefficient of 1 were obtained. Conclusions: The results, in a population different to the initial one, are an evidence of the ability of this methodology for objectively and quantitatively diagnosing the normal, L-SIL and H-SIL cells, as well as for clarifying the ASCUS cells diagnosis, based on fractal dimension and IMH concept and variability.
Keywords : Cancer; Cervix; Fractal; Cytology; Diagnosis.