Services on Demand
Journal
Article
Indicators
Cited by SciELO
Access statistics
Related links
Cited by Google
Similars in SciELO
Similars in Google
Share
Revista Colombiana de Reumatología
Print version ISSN 0121-8123
Abstract
ZULUAGA GOMEZ, Liliana María; VELASQUEZ FRANCO, Carlos Jaime; HERNANDEZ FORONDA, John Camilo and CASTANO ALZATE, Carlos Felipe. Rituximab use in a patient with diffuse necrotizing anterior scleritis associated to c-ancas vasculitis refractory to conventional inmunomodulators. Rev.Colomb.Reumatol. [online]. 2012, vol.19, n.3, pp.183-189. ISSN 0121-8123.
Scleritis is a rare disease characterized by inflammation of sclera and underlying infectious or systemic disease. Severe cases can compromise vision and cause scleral necrosis and eye perforation. c-ANCA associated vasculitis, a systemic syndrome could cause scleritis. Traditional treatment consists of antinflammatory and immunomodulators administration. Refractory cases could be treated with monoclonal antibodies. We report the case of a woman with diffuse necrotizing anterior scleritis associated to c-ANCA refractory to immunosupressants, such as cyclophosphamide in which only Rituximab could induce remission.
Keywords : Scleritis; anti-neutrophil cytoplasmic antibody-associated vasculitis; rituximab; therapy.