Abstract

RANGEL, Carmen Rosa; ROJAS, Silvia; LOPEZ, Mileidys  and  CAVIEDES, Giovanni. Prevalence and risk factors related with adverse reactions to drugs in patients from Hospital Universitario Hernando Moncaleano Perdomo. Revista médica Risaralda [online]. 2016, vol.22, n.2, pp.87-90. ISSN 0122-0667.

Objective: estimate the prevalence and the associated factors to presenting adverse reactions for medicines in patients treated for internal medicine of the Hernando MoncaleanoPerdomo university hospital (HMPUH) for two months. Methods: prospective study of transversal cut. Statistical analysis was carried it out with Epi info v7.0. Results: from the 284 patients, it obtained 89 adverse reactions for medicines (ADR) that come from to 31.34% of sample, the 52,4% were male with an average age of 58,5 years old. The ADR were classified according to their production mechanism in A sort 79%, B sort 14% and C sort 5%; the majority were minor in the 88% of cases. The main pharmacological system affected was the gastrointestinal followed by the hematological in 22% and 19% respectively; the enoxaparin was the main drug associated with the ADR production in the 17%, so is the drug with more drug interactions together to the acetylsalicylic acid in the 26% of the cases. Among the associated factors for the ADR production are the polypharmacy IC: 1.96-5.57, p 0.000027 and the drug interactions IC: 1.32 - 3.81, p 0.0011. Conclusions: the drug interactions and the polypharmacyare the associated factors to the presence of adverse reactions to medicines in internal medicine patients.

Keywords : Abnormalities; Drug-Induced; Drug Combinations; Drug Interactions.

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