Services on Demand
Journal
Article
Indicators
- Cited by SciELO
- Access statistics
Related links
- Cited by Google
- Similars in SciELO
- Similars in Google
Share
Revista U.D.C.A Actualidad & Divulgación Científica
Print version ISSN 0123-4226
Abstract
CRISTANCHO LIEVANO, Felipe; TRUJILLO GAMA, Esperanza and BRAVO HERNANDEZ, María Mercedes. CAG PATHOGENICITY ISLAND OF Helicobacter pylori AND ITS ASSOCIATION TO PRENEOPLASTIC LESIONS AND GASTRIC CANCER. rev.udcaactual.divulg.cient. [online]. 2018, vol.21, n.2, pp.309-318. ISSN 0123-4226. https://doi.org/10.31910/rudca.v21.n2.2018.972.
Gastric cancer is one of the main causes of death by cancer in the world and the infection with Helicobacter pylori is one of the main risk factors associated with its appearance. Helicobacter pylori is a bacterium that colonizes the gastric mucosa, infecting about half of the world´s population. The pathological effects caused by infections with H. pylori greatly depend on an IV type secretion system encoded in the cag pathogenicity island (cagPAI). In this review, we describe the composition of the cagPAI, the alterations of cellular signaling pathways mediated by cagPAI which regulate oncogenic cellular responses that may increase the risk of malignant transformation associated with the infection and the importance of polymorphisms in cagPAI genes as potential markers of progression to gastric cancer.
Keywords : stomach cancer; genomic islands; precancerous condition; genetic.