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Revista de Salud Pública
Print version ISSN 0124-0064
Abstract
AMARO-TERRAZOS, Jony Z.; IPARRAGUIRRE, María E. and ISLA-PONCIANO, Pamela C.. Effect of consumption of alfalfa extract (Medicago sativa) on induced iron deficiency anemia in mice (Mus musculus). Rev. salud pública [online]. 2018, vol.20, n.6, pp.730-734. Epub Oct 20, 2020. ISSN 0124-0064. https://doi.org/10.15446/rsap.v20n6.65795.
Objective
To determine the effect of alfalfa extract consumption on induced iron deficiency anemia in mice.
Materials and Methods
Thirty M. musculus albino mice of the BALB/c strain were used for this study. All of them were males, with a mean weight of 23±33.7 g. Three groups of 10 mice each were formed: a) negative control group with sufficient iron (HS), which received 40g/d of balanced feed for seven weeks; b) positive control group with iron deficiency (HD), which received 40g/d of a diet plan for anemia for seven weeks; and c) experimental group with iron deficiency (HD), which received 40g/d of a diet plan for anemia for seven weeks and 20g/d of alfalfa extract (EA) from week five. Hemoglobin levels were measured.
Results
At the end of the treatment, a significant difference was observed in hemoglobin levels between the positive (8.41±3.9 g/dL) and experimental (13.4±3.3 g/dL) control groups (T student, p<0.05). There was no significant difference in hemoglobin levels at the end of the induction period between the positive (8.76±3.9 g /dL) and experimental (8.59±3.1 g/dL) groups (T student, p>0.05).
Conclusions
Under experimental conditions, alfalfa has an antianemic effect based on the results of hemoglobin levels.
Keywords : Anemia iron-deficiency; medicago sativa; nutrition public health; iron; diet; disease (source: MeSH, NLM).