Abstract

GONZALEZ-JIMENEZ, Edgar E.. Multifunctional nanostructured platform for sequential release of therapeutic molecules. Rev. acad. colomb. cienc. exact. fis. nat. [online]. 2022, vol.46, n.179, pp.339-355.  Epub Sep 06, 2023. ISSN 0370-3908.  https://doi.org/10.18257/raccefyn.1660.

From synthesized metallic double-walled single-pore nanoboxes (DWSPNb) by Kirkendall effect and galvanic replacement, a potential nanostructured multifunctional platform with the capacity for sequential release of molecular agents for therapeutic use is proposed. To evaluate the platform, numerical methods based on the dimensions, morphology, and composition of the synthesized nanoboxes were performed. For combinations of two pharmacological molecules of interest, the diffusion coefficients were determined as a function of the distance to the walls of the nanobox and the concentration. The simulation carried out for the release of these two molecules from the internal cavity and the nanochannel formed between the two walls of the nanobox showed the required sequential kinetics. This behavior allows to schedule controlled deliveries in time and place to reduce resistance to dual drugs and consequently optimize the necessary dose, as well as avoid any derived secondary effects. The metallic composition turned the nanobox into an opto-thermal nanoantenna enabling the control of cargo release and delivery through polymers sensitive to temperature and, additionally, its potential use for photodynamic treatment and diagnostic imaging.

Keywords : Nanoplatform; Sequential release; Nanoboxes; Drug delivery; Nanoantenna; Molecular diffusion.

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