Abstract

ISAZA, Carlos; SEPULVEDA-ARIAS, Juan C.  and  HENAO, Julieta. Pharmacogenomics in medicine. Colomb. Med. [online]. 2009, vol.40, n.3, pp.327-346. ISSN 1657-9534.

Introduction: Pharmacogenomics studies how changes in the genome influence the response to drugs. Its main medical value consists in: i) the identification of individuals in which it is possible to predict if certain drug and dose will be effective or on the contrary, if the drug must be avoided due to its high toxicity risk or because the patient will never respond to it; ii) to identify molecular targets able to be intervened by drugs. Objective: To carry out a systematic review about pharmacogenomic oriented to the use and clinical impact of drugs. Methodology: The pertinent biomedical literature was searched in several databases such as Medline, Proquest, Science Direct, Ovid and Cochrane, as well as the available information in web sites of international sanitary organizations.

Keywords : Pharmacogenetics; Pharmacogenomics.

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