Abstract

MORALES, Angie Carolina; MORALES, Adriana Cruz; TABORDA VANEGAS, Natalia A.  and  CARDONA MAYA, Walter D.. Effect of Marijuana Use on Human Semen Parameters: In Vivo Approach. Urol. Colomb. [online]. 2022, vol.31, n.4, pp.155-161.  Epub June 05, 2024. ISSN 2027-0119.  https://doi.org/10.1055/s-0042-1758465.

Evidence suggests that exposure to psychoactive substances is related to spermatogenesis alterations that affect sperm quality. The objective of the present work was to determine sperm parameters in regular users of marijuana cigarettes. Seminal samples from 42 active consumers of marijuana cigarettes and 16 volunteer non-marijuana users were analyzed. Through a semen analysis, we identify conventional seminal parameters (viability, motility, morphology, and sperm concentration) according to the guidelines established by the World Health Organization (WHO). The antioxidant effect of the seminal plasma was evaluated through the determination of the percentage of inhibition of the stable radical 1,1-diphenyl-2-picrylhydrazyl. The median values of consumers with respect to the control group were respectively: volume - 2.98 mL versus 3.95 mL (p = 0.0221); total concentration - 189 million/mL versus 291.1 million/mL (p= 0.0636); progressive motility - 50% versus 56.5% (p = 0.0052); viability - 65.3% versus 73.1% (p = 0.0732); and normal morphology - 5% versus 7% (p = 0.0167). The results obtained in the present study indicate that the consumption of marijuana cigarettes negatively affects progressive motility, normal morphology, and total sperm concentration. In addition, the total sperm concentration is affected by the frequency of consumption of marijuana cigarettes.

Keywords : marijuana; cannabis sativa; seminal analysis; seminal parameters; consumption.

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