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Revista Colombiana de Nefrología
On-line version ISSN 2500-5006
Abstract
GIRALDO OCAMPO, Christian Camilo; JIMENEZ BEJARANO, María Fernanda and SERNA FLOREZ, Jhon. Rapidly progressive glomerulonephritis secondary to pauciinmune vasculitis, a rare entity: case report and review of the literatura. Rev. colom. nefrol. [online]. 2022, vol.9, n.2, 402. Epub Aug 01, 2022. ISSN 2500-5006. https://doi.org/10.22265/acnef.9.2.555.
Introduction
Vasculitis associated with antineutrophil cytoplasmic antibodies (ANCA) are a heterogeneous group of pathologies; characterized by the inflammation and destruction of small and medium caliber blood vessels associated with the presence of circulating ANCA. They present with a wide variety of signs and symptoms and, if left untreated, lead to high morbidity and mortality; They are a rare cause of rapidly progressive glomerulonephritis and acute kidney injury requiring renal support, which is why a high index of suspicion is required in the initial approach.
Purpose
This article seeks to sensitize the medical personnel for the need of an active search for vasculitis as a cause of glomerulonephritis and the impact of early diagnosis and treatment in the patient's clinical condition.
Case presentation
We report the case of a 65-year-old male patient treated in a reference hospital in the city of Pereira, Risaralda, who debuted with rapidly progressive glomerulonephritis secondary to microscopic polyangiitis in his postoperative period of a prostatectomy, progressing to acute kidney injury needing to start renal support such as intermittent hemodialysis; after performing a renal biopsy and autoimmunity profile, the diagnosis of microscopic polyangiitis-type vasculitis is confirmed, specific immunosuppressive management is initiated, which achieves remission of the disease and with it an improvement in renal function that allows the suspension of renal replacement therapy, y, currently a patient He remains asymptomatic, with remission, with immunosuppressive management, attending outpatient controls with nephrology without mention of complications secondary to pharmacological therapy.
Discussion and conclusion
In antineutrophil cytoplasmic antibody(ANCA)-Associated Vasculitis , timely diagnosis and the establishment of adequate immunomodulatory therapy are the fundamental pillars in the approach to this entity. A late diagnosis is directly related to a poor short-term prognosis. Timely diagnosis requires an appropriate index of suspicion.
Keywords : Case report; Acute kidney injury; Glomerulonephritis; Vasculitis; renal biopsy..