Images in internal medicine
Fibrothorax. Remembering the tragedy
Óscar Mateo Pardo-Rodrígueza
*
Humberto Carlo Parra-Bonillab
a Médico Cirujano Universidad Nacional de Colombia, Médico Hospitalario Servicio de Cirugía General E.S.E. Hospital Universitario La Samaritana. Bogotá D.C. (Colombia).
b Médico Internista Pontificia Universidad Javeriana. Médico Internista E.S.E. Hospital Universitaio La Samaritana Bogotá. Especialista en Epidemiología Colegio Mayor de Nuestra Señora del Rosario. Bogotá D.C. (Colombia).
A 69-year-old male with high blood pressure, 50% LVEF heart failure, oxygen-dependent chronic obstructive pulmonary disease, a heavy smoking history and treated pulmonary tuberculosis was admitted to the emergency room due to mMRC 4/4 dyspnea, productive cough with yellow sputum, non-quantified fever, and diminished breath sounds. A chest x-ray showed left-sided diffuse heterogenous radiopacity and a high-resolution CT revealed left fibrothorax.
Fibrothorax is defined as the sequela of intense pleural inflammation, causing thickening and fibrosis 1,2. Transforming growth factor-beta (TGF-|3) plays the most important role 3. It occurs most often as a complication of empyema and hemothorax, but also in pulmonary tuberculosis, connective tissue diseases, uremia, paragonimiasis, radiation therapy, asbestosis and with medications such as ergot alkaloids 2-4. It is diagnosed by imaging. Treatment may be pharmacological, using systemic corticosteroids, or surgical with decortication 2,5. It has been associated with lung cancer 6.
Referencias
1. Sulaiman S, Fasanya A, and Thirumala R. Extensive Calcified Fibrothorax. Am J Respir Crit Care Med Vol 195, Iss 4, pp e25-e26, Feb 15, 2017
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2. Light RW, Lee YCG. Pneumothorax, chylothorax. hemothorax, and fibrothorax. In: Broaddus CV, Mason RJ, Ernst JD, King TE Jr, Lazarus SC, Murray JF, Nadel JA, Slutsky A, Gotway M, editors. Murray & Nadel's textbook of respiratory medicine, 6th ed. Philadelphia, PA: Elsevier Saunders; 2015:1439-1460
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3. Michael A. Jantz, Veena B. Antony, Pleural Fibrosis. Clinics in Chest Medicine, Volume 27, Issue 2, 181 - 19
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4. Nachiappan, A. Et Al. Pulmonary Tuberculosis: Role of Radiology in Diagnosis and Management. RadioGraphics 2017; 37:52-72. Jan -Feb, 2017
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5. Hanane, Asri H & Zegmout, A. Historic sequelae of lung tuberculosis. Pan African Medical Journal. 2018;30:210. June, 2018.
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6. Xu H, Koo HJ, Lee HN, Lim S, Lee JW, Choi CM, Kim MY.Lung Cancer in Patients With Tuberculous Fibrothorax and Empyema: Computed Tomography and 18F-Fluorodeoxyglucose Positron Emission Tomography Findings. Journal Comput Assist Tomogr. 2017 Sep/Oct;41(5):772-778.
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