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Acta Medica Colombiana
versión impresa ISSN 0120-2448
Resumen
GOMEZ, Fernando; CURCIO, Carmen-Lucía y BENJUMEA, Ángela-María. The hypothalamic pituitary adrenal axis (HPA) in aging Salivary cortisol in the elderly. Acta Med Colomb [online]. 2016, vol.41, n.2, pp.130-137. ISSN 0120-2448.
Introduction:
salivary cortisol has been frequently used as a marker of stress. Cortisol has an important diurnal rhythm with peak elevations at the dawn hours, called cortisol awakening response (CAR) with a drop during the day. Aging changes in the hypothalamic pituitary adrenal (HPA) axis are contradictory.
Objective:
this study examines the diurnal variation of salivary cortisol levels in elderly subjects living in the community.
Design:
a descriptive cross-sectional study.
Medium:
populational. Participants of IMIAS study (International Mobility in Aging Study).
Participants:
four hundred and fifty people over 65, men and women with a subsample (100) for the sampling of salivary cortisol.
Measurements:
participants collected ten saliva samples, five per day, for two days in this way: when getting up, 30 minutes (half an hour) after waking up, an hour after waking up, in the afternoon at 3 pm and at bedtime. Cortisol was assessed by enzyme radioimmunoassay. CAR, the area under the curve and the curve of diurnal pattern were evaluated.
Results:
an amputee CAR with a flattened diurnal profile and lower levels at night was found. Curve pattern found is considered a "normal" pattern of circadian rhythm of cortisol aging, characterized by having a low CAR and a slow fall throughout the day.
Conclusions:
The elderly have a lower cortisol response to awakening with a reduced diurnal rhythm probably involving an altered HPA axis regulation with aging. (Acta Med Colomb 2016; 41: 130-137).
Palabras clave : salivary cortisol; aging; age-related changes; divinal rhythm.