Introduction:

The gestational trophoblastic disease represents a spectrum of diseases with a common denominator that serves as a marker for diagnosis, monitoring, prognoses and follow-up, the Subunit Beta Human Chorionic Gonadotropin. We review the behavior of gestational trophoblastic disease in a cancer center of third level.

Materials and Methods:

A retrospective cohort of patients referred to the institution on Caldas department from january 2001 to december 2014, with a diagnosis of gestational trophoblastic disease for analyzing treatment and evolution variables.

Results:

From 25 patients with median age of 30 years; 68% had symptoms for less than three months; 84% are diagnosed by ultrasound and 80% by curettage; 52% with persistent mole and 24% with choriocarcinoma; 80% clinical stage I, stage III 8% and 8% in stage IV with metastatic to lung 36%, 18% to central nervous system and 9% to liver; 76% classified as low risk; mean follow-up between diagnosis and remission was 6.3 months, between surgery and remission of 6.4 months and between the first chemotherapy and remission 2.9 months. The overall survival was 92%.

Conclusion:

The factors of greater importance in the occurrence and evolution of gestational trophoblastic disease are the level of the Subunit Beta Human Chorionic Gonadotropin, histology, presence or non-metastatic disease, the use of multi-agent chemotherapy and finally the international prognostic index. MÉD.UIS. 2017;30(3):39-49.

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