Resumen

JUY, M. I.; OREJAS, J. A.  y  LUCCA, M. E.. Study of itaconic acid production by Aspergillus terrus MJL05 strain with different variable. Rev. colomb. biotecnol [online]. 2010, vol.12, n.2, pp.187-193. ISSN 0123-3475.

Itaconic acid (IA) production by Aspergillus terreus MJL05 strain was investigated in submerged batch fermentation in a stirred bioreactor to determine the effect of varying the nitrogen, phosphorous and carbon sources concentrations in the production medium. Glycerol, a biodiesel by-product was reported as an efficient substrate to achieve high itaconic acid productivities. This was used as the sole carbon source. The resulting C:N 18, N:P 10.8 and C:P 195 ratios were selected as the best and allowed to improve IA concentration from 11.0 to 27.6 g/l with a volumetric productivity of 0.192 g IA/l.h and a specific productivity 0.013 g IA/g biomass.h. Bioprocess yields, Yx:s 0.27 g d.w. biomass/g substrate; Yp:x 1.63 g IA/g d.w. biomass and Yp:s 0.44 g IA/g substrate, allowed to assume the feasibility of using this strain for IA production.

Palabras clave : Itaconic acid; Aspergillus terreus; glycerol.

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