Resumen

CRUZ, Ana J. F et al. Evaluation of the Antibacterial and Modulating Activity of Methanolic and Hexanic Extracts of the Allium Cepa. Rev. Cienc. Salud [online]. 2016, vol.14, n.2, pp.191-200. ISSN 1692-7273.  https://doi.org/10.12804/revsalud14.02.2016.04.

Introduction: Bacterial resistance has grown significantly in recent years, making the search for new antibiotics imperative. Bioactive compounds in some medicinal plants may exhibit various biological activities as antimicrobial activity. Allium cepa, popularly known as onion, is ethnopharmacologically used for treating various diseases, such as tuberculosis, diabetes, hypertension and rheumatism; it is also considered a powerful bactericide. Objective: The main objective of this study was to evaluate the antimicrobial and modulating activity of methanol and hexane extracts of A. cepa against the strains of multiresistant bacteria. Materials and methods: Microdilution and modulation of antibiotics. Results: The results showed a variation in the MIC (Minimum Inhibitory Concentration) from 128 to ≥ 1024μg / mL between A. cepa methanol (EMAC) and A. cepa hexane (EHAC) extracts. Modulation with aminoglycosides (gentamicin and amikacin) have proved to have antagonistic effects of the extracts sinérgicose EHAC and EMAC against strains of multiresistant Escherichia coli and Staphylococcus aureus. Further research is needed related to the use of medicinal plants combined with antimicrobials against pathogenic strains. Conclusion: Through these results it can be inferred that natural products could constitute a promising source for combating bacterial resistance.

Palabras clave : Allium cepa; Antimicrobial activity; M.I.C., Modulatory effect; Escherichia coli; Staphylococcus aureus.

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