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Revista de la Facultad de Medicina
versión impresa ISSN 0120-0011
Resumen
BOLIVAR-BARBOSA, Janeth Alejandra y RODRIGUEZ-VARGAS, Ariadna Lorena. Neurotoxical activity of Micrurus snake venom and methods for its analysis. A literature review. rev.fac.med. [online]. 2020, vol.68, n.3, pp.453-462. Epub 25-Nov-2020. ISSN 0120-0011. https://doi.org/10.15446/revfacmed.v68n3.75992.
Introduction:
Snakes of the genus Micrurus have fossorial habits, passive temperament and scarce production of powerful venom with neurotoxic characteristics that block the synaptic transmission at the neuromuscular junction.
Objective:
To present an overview of the neurotoxicity of the Micrurus snake venom, and its functional characterization by ex vivo analysis methods.
Materials and methods:
A literature review was conducted in MedLine and ScienceDirect using specific terms and their combinations. Search strategy: type of studies: articles on the neurotoxicity of Micrurus snake venom and techniques to determine its neurotoxic activity by in vitro, in vivo and ex vivo models; publication period: articles published until June 2018; publication language: English and Spanish.
Results:
Out of 88 studies identified in the initial search, 28 were excluded because they did not meet the inclusion criteria (based on reading their titles and abstracts). 8 additional articles (books and reports) were included, since, according to the authors' opinion, they complemented the information reported by the selected studies. The studies included in the review (n=68) were original research papers (n=44), review articles (n = 16), and book chapters, reports, guides and online consultations (n=8).
Conclusions:
Studies performed using ex vivo muscle and nerve preparations to evaluate the effect of neurotoxins provide a good model for the characterization of the pre-synaptic and post-synaptic effect of the venom produced by snakes of the genus Micrurus.
Palabras clave : Elapidae; Micrurus; Phospholipases A2; Neuromuscular Junction (MeSH).