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Revista Colombiana de Ciencias Pecuarias
versión impresa ISSN 0120-0690versión On-line ISSN 2256-2958
Resumen
OLIVERA A, Martha; TARAZONA M, Ariel; RUIZ C, Tatiana y GIRALDO E, Carlos. Bovine luteolysis: intracellular signals. Rev Colom Cienc Pecua [online]. 2007, vol.20, n.3, pp.387-393. ISSN 0120-0690.
The corpus luteum is a transient gland that produces progesterone during a period of time that is determined by the length of gestation. When there is no gestation the corpus luteum undergoes regression, a process commonly known as luteolysis. This process has been divided in: functional, since there is a lost of the capacity to synthesize progesterone; and structural, because there is a disruption of the cellular structure. PGF2α, is the principal luteolytic factor, but there are other parallel pathway mediated by calcium, cytokines, reactive oxygen species and endothelins. All these routes end up in inhibition of steroidogenesis and/or apoptosis. In this article we try to integrate the information present in the literature and propose a map depicting the major cellular and molecular events taking place in this process that is fundamental en bovine reproduction.
Palabras clave : apoptosis; oxitocin; PGF2α; steroidogenesis inhibition.