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Biomédica
versión impresa ISSN 0120-4157versión On-line ISSN 2590-7379
Resumen
MARQUEZ, Adriana Isabel et al. Pulmonary and central nervous system nocardiosis: Alcoholism as an immunocompromising factor. Biomed. [online]. 2023, vol.43, n.1, pp.37-43. Epub 30-Mar-2023. ISSN 0120-4157. https://doi.org/10.7705/biomedica.6606.
Nocardiosis is a disease with worldwide distribution. It is usually found in tropical areas and mainly affects immunocompromised patients, however, there are also cases where its infection has been reported in immunocompetent patients. This pathology is caused by bacteria known as Nocardia spp., which are gram-positive microorganisms and environmental saprophytes, and although exposure to Nocardia spp. is almost universal, only a small fraction of exposed people develops the disease.
We present the case of a 47-year-old man, with no evidence of immunosuppression, from a rural area of Boyacá, who was admitted due to intense and intermittent headache accompanied by paresthesia and, finally, a decrease in consciousness. A brain magnetic resonance was performed and evidenced a fronto-temporo- occipital space-occupying lesion in the cortico-subcortical region with a compressive effect and displacement of the ventricular system cavities. It was suspected at first a neoplastic lesion or a brain abscess. The lesion was surgically resected, and its culture showed Nocardia africana/nova. In later studies a possible primary pulmonary focus was evidenced. Alcoholism was the only risk factor documented. The patient completed 6 weeks of hospital antibiotic treatment with favorable clinical and radiological evolution and was discharged with a 1-year plan of outpatient antibiotic therapy. Although Nocardia spp. mainly affects immunocompromised patients, evidence shows that this microorganism can also be a threat to individuals without traditional immunosuppression risk factors.
Palabras clave : Nocardia; Nocardia infections; brain abscess; alcoholism; immunocompetence; immunocompromised host.