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Revista de la Universidad Industrial de Santander. Salud
versión impresa ISSN 0121-0807
Resumen
GUIO-MAHECHA, Elizabeth et al. Quality control of human biological material for use in research. Rev. Univ. Ind. Santander. Salud [online]. 2016, vol.48, n.3, pp.393-409. ISSN 0121-0807. https://doi.org/10.18273/revsal.v48n3-2016013.
Human biological material provides valuable information about levels of metabolites associated with the development of certain diseases, becoming an important tool for monitoring responses to treatment or even identifying new intervention mechanisms. The procedures to what the biological material are exposed from their preparation to their analytical phase are called pre-analytical variables, which can have a direct effect the detection of metabolites, and therefore, on the results of the research projects, particularly in the absence of standardized processes that confirm the quality control of the biological material. This technical note highlights some critical points that must be parameterized in the biocollections for research purposes to ensure high standards of quality and reproducibility in observational studies, where any kind of bias caused by the pre-analytical variables is minimized. In addition, it is intended to identify the importance of the development of biobanks for research purposes in our country in order to have human biological material of high quality.
Palabras clave : Biobank; biocollections; pre-analytical variables; metabolites; biomarkers; quality control; traceability; human biological material.