Objective:

To clarify the association between miR-146a, miR-499, and IRAK1 polymorphism and systemic lupus erythematosus (SLE) predisposition.

Methods:

A literature search was conducted until 12 September 2020 in accordance with the PRISMA guidelines. The keywords "miRNA-146a", "miRNA-499", "IRAK1" and "SLE" were used in combination to obtain case-control studies evaluating the abovementioned gene polymorphism and the risk of SLE.

Results:

Patients harbouring C allele of miRNA-146a rs2431697 exhibited low SLE risk (CC vs. TC + TT, OR = .77, 95% CI = .62-.95, p = .019; TC vs. CC + TT, OR = .84, 95% CI = .71-.98, p = .027; and TC vs. TT, OR = .73, 95% CI = .61-.86, p = .000), whereas patients carrying the A allele and AA genotype of rs3027898 in IRAK1 had significantly decreased SLE susceptibility (A vs. C, OR = .73, 95% CI = .60-.87, p = .001; AA vs. CA + CC, OR = .64, 95% CI = .42-.97, p = .037; AA + CA vs. CC, OR = .71, 95% CI = .56-.88, p = .003, and AA vs. CC, OR = .49, 95% CI = .31-.77, p = .002). No association was observed between miRNA-146a rs2910164 and miRNA-499 rs3746444 with SLE risk.

Conclusion:

This study demonstrates associations between miRNA-146a and IRAK1 polymor phisms with SLE risk. Larger studies on these associations are needed in the future to support our results.

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