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Ingeniería y competitividad
versión impresa ISSN 0123-3033
Resumen
ROA, Diego A. y URBINA, Juan Manuel. 2-Phenyl lepidines preparation through microwave assisted Friedel-Crafts alkylation of N-( α -allylbenzyl) anilines supported on silica-sulfuric acid . Ing. compet. [online]. 2013, vol.15, n.1, pp.71-77. ISSN 0123-3033.
Silica sulfuric acid (SSA) has been efficiently used as solid support in the solvent free microwave assisted synthesis of 2-phenyl lepidines (2-phenyl-4-methylquinolines) from N-(α-allylbenzyl)anilines. Reactions proceed through a two step cascade involving a Friedel-Crafts alkylation + oxidation of the formed 2-phenyltetrahydrolepidines. Good to high reaction yields and short reaction times were observed. Prepared products were identical to the ones already prepared in our lab through a two step synthesis
Palabras clave : Microwave assisted organic synthesis; silica sulfuric acid; 2-phenyl lepidine.