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Universidad y Salud
versión impresa ISSN 0124-7107versión On-line ISSN 2389-7066
Resumen
MAURO-MARTIN, Ismael San et al. Detection of impaired glucidic metabolism and insulin resistance in a pilot child sample. Univ. Salud [online]. 2019, vol.21, n.3, pp.191-197. ISSN 0124-7107. https://doi.org/10.22267/rus.192103.155.
Introduction:
Metabolomics enables the study of insulin resistance (IR), a risk factor for pre-diabetes and diabetes. Quantose IRTM is the only test that measures IR using the euglycemic hyperinsulinemic clamp.
Objective:
The effectiveness of a metabolomic test for the detection of RI markers in a child population was verified.
Materials and methods:
Eleven children aged 8.54 ± 3.53 years with diabetes risk factors were recruited from the El Escorial Hospital. The American Diabetes Association (ADA) Standards (5,7-6,4% HbA1C and 100-125 mg/dl basal glucose) were established as diagnostic criteria for prediabetes. Blood tests were compared to the Quantose IRTM assay studying the metabolomic profile related to IR (alpha-hydroxybutyric acid, oleic acid, linoleo-glycerophosphocoline and insulin). This analysis generated a Quantose © score of IR > 63.
Results:
None of the subjects met the ADA criteria for prediabetes: HbA1C=5,3±0,18 and glucose=86,6± 5,6 mg/dl. On the contrary, 10 subjects met the Quantose IRTM test criterion for IR (score: 78,09 ± 9,24 (>63)).
Conclusions:
The Quantose IRTM test measures the percentage of glucose bound hemoglobin within red blood cells. This assay makes it possible to predict diabetes risk and take preventive measures.
Palabras clave : Diabetes mellitus; insulin resistance; metabolomics; carbohydrate metabolism; child.