Objective.

To evaluate the efficacy of the combination of two local estrogenic therapies with a vaginal lubricant (K-Y gel), to control the symptoms of the severe atrophic vulvovaginitis.

Materials and methods.

Prospective, controlled and randomized study. Fifty-seven postmenopausal women treated by the author in the climacteric consultation, between July 2014 and July 2016 were included. Two groups were established, 30 women received twice a week 0.625 mg intrava-ginal conjugated equine estrogens (group A), and 27 Women received twice a week during six months Estriol at doses of 0.5 mg intravaginal (group B). Both groups received, in addition to the hormonal therapy, 5 grams of intravaginal lubricant every 6 hours. In order to evaluate the hormonal status of all women, before starting and six months later, their vaginal maturity index was determined, simultaneously, the vaginal health index was calculated monthly in each control.

Results.

The women of group A showed a symptoms reduction, at the end of the study, of 72% compared to 87% of group B. None of the women presented complications related to therapy.

Conclusions.

The use of local estrogen therapy, in severe atrophic vulvovaginitis, is a well-tolerated measure; after six months of monitoring, a significant improvement of the symptoms and the vaginal health index is evidenced. The use of estriol with lubricant was associated with better results and less adverse effects, compared to conjugated equine estrogens and lubricant; however, the rates of sexual satisfaction were similar.

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