SciELO - Scientific Electronic Library Online

 
vol.32 número2Virus chikungunya: Características virales y evolución genéticaValoración cuantitativa para la reincorporación ocupacional índice de autoresíndice de materiabúsqueda de artículos
Home Pagelista alfabética de revistas  

Servicios Personalizados

Revista

Articulo

Indicadores

Links relacionados

  • En proceso de indezaciónCitado por Google
  • No hay articulos similaresSimilares en SciELO
  • En proceso de indezaciónSimilares en Google

Compartir


Revista Salud Uninorte

versión impresa ISSN 0120-5552versión On-line ISSN 2011-7531

Resumen

RODRIGUEZ SANJUAN, Alexander; CERVERA, Eliana; VALENCIA VILLA, Gerardo  y  VILLALBA AMARIS, Pedro J. Review: Neuronal and glial biomarkers as quantitative approach to classify the severity of traumatic brain injury. Salud, Barranquilla [online]. 2016, vol.32, n.2, pp.302-318. ISSN 0120-5552.

Abstract It has been highlighted the potential of early neurological inaccurate assessment of severity in patients with head trauma; in some cases, for example, the severity of the injury is overestimated or underestimated. The aforementioned situation has led to the search of biomarkers associated with early brain injury. Research in this field has exponentially increased over the past 20 years, with a higher publication ramp in the last 10 years. The results range from promising findings to other sometime inconclusive. An ideal biomarker should be able to demonstrate high sensitivity and specificity for brain injury, among others aspects. Literature has shown that there is not a single biomarker that can predict patient's clinical decline with high sensitivity and specificity correlation. Instead, it is required to use a panel of markers that reflect different aspects of traumatic brain injury. In this paper, we conducted a review of the most promising biomarkers studied as predictors of severity of head trauma, with special focus on their nature, location, basal concentrations, blood half-life and methods by which they can be quantified in blood samples.

Palabras clave : traumatic brain injury; biomarkers; prognosis; traumatic brain bleeding.

        · resumen en Español     · texto en Español     · Español ( pdf )

 

Creative Commons License Todo el contenido de esta revista, excepto dónde está identificado, está bajo una Licencia Creative Commons