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Universidad y Salud
versión impresa ISSN 0124-7107versión On-line ISSN 2389-7066
Resumen
GUZMAN, Kevin Andrés y PAZOS, Alvaro. Helicobacter pylori: Pathogenic or mutualistic microorganism in Colombian populations. Univ. Salud [online]. 2023, vol.25, n.1, pp.1-6. Epub 31-Ene-2023. ISSN 0124-7107. https://doi.org/10.22267/rus.232501.292.
Introduction:
The risk to develop gastric cancer varies between continents, countries and regions. Although there is a high prevalence of Helicobater pylori, its role as either pathogen or mutualistic bacteria defines the risk of gastric cancer in Colombian regions.
Objective:
To discuss the role of Helicobacter pylori in the risk of gastric cancer in Colombia.
Materials and methods:
A literature review based on searching LILACS, SciELO, and PubMed databases.
Results:
Helicobacter pylori role as either a pathogen or mutualistic microorganism associated with gastric cancer risk in Colombia can be explained by analyzing elements such as: human and Helicobacter pylori coevolution; cagA and vacA gene virulence; inflammatory (Th1) or anti-inflammatory (Th2) responses induced by Helicobacter pylori; human susceptibility to gastric cancer (IL1β, IL10); diet; and environmental factors.
Conclusions:
Even though Helicobacter pylori has a mutualistic role in populations at low gastric cancer risk (coastal regions), its role as a pathogen in populations at higher risk (Andean regions) justifies its eradication as a key strategy to mitigate the incidence of this cancer in Colombia.
Palabras clave : Helicobacter pylori; incidence; Stomach Neoplasms; risk factors; biological coevolution.