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Medicas UIS
versão impressa ISSN 0121-0319versão On-line ISSN 1794-5240
Resumo
DUARTE-DONNEYS, Lili M. et al. Vitamin D deficiency in children and adolescents receiving antiepileptic treatment. Descriptive study. Medicas UIS [online]. 2022, vol.35, n.1, pp.71-79. Epub 28-Maio-2022. ISSN 0121-0319. https://doi.org/10.18273/revmed.v35n1-2022007.
Hypovitaminosis D is a prevalent problem in the general population and very common in children; related to different pathologies or factors such as the use of antiepileptic drugs (MAEs), mainly those enzymatic inducers of cytochrome P450, broadly related with bone health. Reason why this study seeks to determine the distribution of vitamin D insufficiency in children with epilepsy in pharmacological treatment and to establish associated factors based on sociodemographic, clinical, and therapeutic characteristics.
Methodology:
descriptive, cross- sectional, retrospective study with 103 patients with epilepsy in management with MAEs, attending the neuropaediatric consultation in a third-level hospital, information was taken from the medical records of children between 0 and 18 years of age during January 2016 and June 2019. A multivariate model was built in relation to the presence of vitamin D insufficiency and its normal values.
Results:
44.7% of patients had vitamin D insufficiency, while 6.8% had deficiency, of which 4 had a history of fractures. A statistically significant association with insufficiency was found in patients residing in rural areas (ORa=4.2 (IC95=1.3-13.4) p=0.013), they belong to a low socio-economic level (Ora=2.9 (95% CI=1.1-77) p=0.030) and suffering from refractory epilepsy (Ora=3.1 (95% CI=1-8.7) p=0.033).
Conclusions:
hypovitaminosis D is frequent in a patient with epilepsy under pharmacological management with MAE. Insufficiency was associated with refractory epilepsy, low socioeconomic status and coming from rural areas, so routine monitoring of vitamin D levels is recommended in those patients with deficits. MÉD.UIS.2022;35(1): 71-9
Palavras-chave : Vitamin D Deficiency; Epilepsy; Anticonvulsants; Bone diseases.
