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versão impressa ISSN 0123-9392
Resumo
VELEZ-PAEZ, Jorge Luis et al. Mean platelet volume as a predictor of mortality in patients with sepsis: systematic review and meta-analysis. Infect. [online]. 2020, vol.24, n.3, pp.162-168. ISSN 0123-9392. https://doi.org/10.22354/in.v24i3.861.
Introduction:
Platelet mean volume (MVP) is a biomarker used in the integral approach to sepsis.
Objective:
To assess the association between MVP and mortality in patients with sepsis.
Methods:
A systematic review of observational studies in five databases was performed. Mortality associated with sepsis was analysed; interventions considered were MPV, APACHE and serum lactate.
Results:
Regarding mortality associated with sepsis, a significant value was found in the MVP at 72 hours (200 deceased versus 654 not deceased; MD 0.83 IC95% 0.53-1.13, p=<0.0001, I2 =72.9%); as well as the value of APACHE II (220 dead versus 604 not deceased; MD 0.81 IC95% 0.62-1.0, p= 0.0001, I2 =32%). No statistical significance was found for the other clinical variables.
Conclusions:
Increased MVP is associated with increased risk of mortality in patients with sepsis, especially after 72 hours of evolution of clinical features.
Palavras-chave : Mean Platelet Volume; Sepsis; Mortality; Systematic Review.