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Medicas UIS
versão impressa ISSN 0121-0319
Resumo
RONDON GONZALEZ, Fernando e GUILLERMO, Barreto. Genetic structure, ancestry and their relationship to human health studies. Medicas UIS [online]. 2013, vol.26, n.1, pp.37-43. ISSN 0121-0319.
The current configuration of human populations is due to the mix of native individuals and many colonizers; it can entail genetic structure, a phenomenon appreciable to observe differences in allele and genotype frequencies of populations of a geographic region over another. This analysis has focused on the identification and quantification of the degree of mixing, useful tool for checking through association of polymorphic markers involved in the development of diseases. One obstacle in identifying genetic variants associated with diseases is the comparison of cases and controls from populations with different genetic backgrounds. In the opposite sense, it is important to establish the degree of genetic structure in populations due to the differential distribution of alleles of polymorphisms associated with a disease of interest. (MÉD.UIS.2013;26(1):37-43).
Palavras-chave : Population genetic structure; Polymorphic markers; Disorders.