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Acta Medica Colombiana
versão impressa ISSN 0120-2448
Resumo
RODRIGUEZ, Martha Patricia et al. Secondary hyperparathyroidism after kidney transplant Experience of a transplant center. Acta Med Colomb [online]. 2016, vol.41, n.2, pp.111-115. ISSN 0120-2448.
Introduction:
chronic kidney disease is associated with severe metabolic abnormalities that lead to secondary hyperparathyroidism (SHPT). Kidney transplant corrects pathophysiological abnormalities that originate it.
Objective:
to describe changes at one year and at three years of follow- up of serum levels of intact parathyroid hormone (PTH) and calcium-phosphorus profile in patients undergoing renal transplantation with a previous diagnosis of SHPT.
Methodology:
a descriptive analysis of all patients transplanted between 2005 and 2012 was performed assessing levels of iPTH and calcium-phosphorus profile before transplantation, and after one year and three years of follow-up.
Results:
pre-transplant iPTH average of 175 patients was 465.4 pg / dL; in 30.2% of patients levels higher to nine times the normal value were found. At one year follow-up, glomerular filtration rate (GFR) average was 65.4 mL / min / 1.73 rtf. PTH (114 patients), averaged 118.7 pg / dL, with an average decrease of 339 pg / dL. PTH was greater in those with GFR less than 40. In the third year of follow-up findings were maintained in all patients with iPTH average of 100.4 pg / dL (a decrease of 396 pg / dL).
Conclusions:
in this study it was found that SHPT improves after renal transplantation, with a significant reduction in iPTH levels to the first and third years of follow-up. (Acta Med Colomb 2016 41: 111-115).
Palavras-chave : secondary hyperparathyroidism; parathyroid hormone; chronic renal failure; kidney transplant.