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Acta Medica Colombiana
versão impressa ISSN 0120-2448
Resumo
GARCIA-RUEDA, Karen Andrea et al. Microbiological diagnosis in febrile neutropenia secondary to chemotherapy for hematologicmalignancy. A cohort description. Acta Med Colomb [online]. 2020, vol.45, n.1, pp.25-31. Epub 15-Maio-2020. ISSN 0120-2448. https://doi.org/10.36104/amc.2020.1386.
Objective:
to describe the demographic, clinical, therapeutic and microbiological characteristics of patients with hematological malignancies undergoing chemotherapy who develop febrile neutropenia during treatment, as well as the mortality at discharge.
Methods:
a retrospective cohort study of patients with hematologic neoplasms who developed febrile neutropenia and were seen at the Hospital Universitario San Vicente Fundación in Medellín.
Results:
records of 110 episodes of febrile neutropenia were obtained. The mean age was 45 years. In 55.4%, a microbiological diagnosis was obtained; bacteremia was documented in 83.8% of these. The most common microorganisms wereK.pneumoniae(30%) andE. coli(18%). Antibiotic resistance due to ESBLs or carbapenemases ingram negativebacilli was 33%. Death occurred in 17% of patients. Acute lymphocytic leukemia (ALL) and acute myeloid leukemia (AML) were the most prevalent underlying diagnoses; the most prevalent clinical focus was bacteremia (24.5%).
Conclusion:
in our case series, there are significant differences in the percentage of patients with bacteremia, as well as in global mortality, compared to the rest of the cohorts in the region. A new research study needs to be carried out to clarify the source of these differences.(Acta Med Colomb 2020; 45. DOI:https://doi.org/10.36104/amc.2020.1386).
Palavras-chave : chemotherapy; microbiology.