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Acta Medica Colombiana
versão impressa ISSN 0120-2448
Resumo
RAMPAKAKIS, EMMANOUIL et al. Prospective observational study evaluating the disease burden of HZ in Colombia. Acta Med Colomb [online]. 2021, vol.46, n.3, pp.11-18. Epub 23-Mar-2022. ISSN 0120-2448. https://doi.org/10.36104/amc.2021.1636.
Introduction:
herpes zoster (HZ) is a debilitating disease with a negative effect on quality of life (QL). This study sought to describe the burden of disease of HZ in Colombia.
Methods:
this was a prospective, observational single-cohort study in 10 Colombian clinical centers. To be eligible, patients had to be immunocompetent, >50 years old, and have a confirmed diagnosis of acute phase HZ or postherpetic pain. The study outcomes included the Zoster Brief Pain Inventory (ZBPI), QL assessed through the EQ-5D questionnaire, and healthcare resource utilization (HCRU) due to HZ. Patients were followed for 180 days.
Results:
154 patients were included with a mean (SD) age of 64.6 (9.6) years. The mean (SD) worst acute pain was 8.2 (2.1), while postherpetic neuralgia (HZ pain >3 which lasted for >90 days) was reported by 36.5% of the patients. The significant predictors of increased pain burden were advanced age and higher worst pain score from the onset of the rash. Increased HZ-related pain was associated with a significant reduction in QL, which lasted approximately 60 days. In terms of HCRU, HZ medications were prescribed for 98.7% of the patients, including acyclovir in 85.1%; 79.2% were followed by a general practitioner; 38.2% were seen in the emergency room and 29.2% consulted a specialist.
Conclusion:
HZ is associated with a significant burden of disease in Colombia, including pain and an impact on QL and HCRU. As the Colombian population ages, strategies should be implemented to more effectively manage and/or prevent the HZ-related burden. (Acta Med Colomb 2021; 46. DOI:https://doi.org/10.36104/amc.2021.1636).
Palavras-chave : herpes zoster; burden of disease; Colombia; postherpetic neuralgia.