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Acta Medica Colombiana
versão impressa ISSN 0120-2448
Resumo
SANCHEZ-RICO, YENY et al. Clinical and histopathological characteristics of diabetic patients with nephrotic proteinuria. A case series. Acta Med Colomb [online]. 2022, vol.47, n.2, pp.20-23. Epub 05-Jan-2023. ISSN 0120-2448. https://doi.org/10.36104/amc.2022.2231.
Objective:
to describe the clinical and histopathological characteristics of diabetic patients with nephrotic-range proteinuria.
Materials and methods:
the kidney biopsies of diabetic patients with nephrotic proteinuria were reviewed. Descriptive analyses were performed along with a comparison of three groups according to the histopathological findings.
Results:
the medical charts of 19 patients from 2018 through 2020 were collected, most of whom (94.7%) were diagnosed with type 2 diabetes mellitus (DM), with an average age of 58 years, and an average duration of DM of 9.9 years (SD: ±7.3). The findings from biopsies performed throughout the years prior to data collection showed that 26.3% had diabetic nephropathy as the only finding, 31.6% had a nephropathy other than diabetic nephropathy, and 42.1% had findings of both diabetic and nondiabetic nephropathy. A comparison of the groups showed a significant difference in the duration of DM, which was greater in patients with diabetic nephropathy (16.4 vs. 5 vs. 9.5 years, respectively, p: 0.024).
Conclusions:
we present a case series of diabetic patients with nephrotic-range proteinuria in Colombia, showing that kidney biopsy lesions other than diabetic nephropathy may be a cause of proteinuria. We found that patients with a report of DN alone had a much longer duration of diabetes. (Acta Med Colomb 2022; 47. DOI:https://doi.org/10.36104/amc.2022.2231).
Palavras-chave : diabetic nephropathies; diabetes mellitus; proteinuria; biopsy; nephrotic syndrome.