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Revista Colombiana de Ciencias Químico - Farmacéuticas
versão impressa ISSN 0034-7418
Resumo
BUSTILLO, Paola; DAZA, María Luisa e SIERRA MARTINEZ, Noralba. Validation of an analytical methodology for the assay of candesartan cilexetil in coated tablets for human use by reverse phase high performance liquid chromatography. Rev. colomb. cienc. quim. farm. [online]. 2014, vol.43, n.1, pp.55-68. ISSN 0034-7418. https://doi.org/10.15446/rcciquifa.v43n1.45464.
A reverse phase high performance liquid chromatographic method was developed for the quantitative assay of candesartan ciletexil in coated tablets for human use as hypotensor agent. The method was then validated for its quantitative determination assay in tablets as pharmaceutical specialties. A C18 column stabilized at room temperature was used and the detection was performed at 306 nm. A mixture of acetonitrile, acetate buffer pH 4,0 (30:70) was used as the mobile phase. The method is selective, linear and shows a good repeatability. The robustness was also studied. These properties besides the simplicity make the methodology convenient for the objective proposed.
Palavras-chave : Candesartan Ciletexil; Reverse high performance liquid chromatography; UV detection; Diode array detector.