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Revista Colombiana de Ciencias Químico - Farmacéuticas
versão impressa ISSN 0034-7418versão On-line ISSN 1909-6356
Resumo
TORRES LEMUS, John Alexander; ROJAS ROJAS, Ángela Patricia e LOPEZ-VALLEJO, Fabián. Molecular docking of the Trypanosoma cruzi dUTPase for identification of inhibitors in Chagas disease treatment. Rev. colomb. cienc. quim. farm. [online]. 2021, vol.50, n.3, pp.740-763. Epub 20-Dez-2023. ISSN 0034-7418. https://doi.org/10.15446/rcciquifa.v50n3.91662.
Introduction:
Chagas disease is endemic to the tropical areas of Latin America and has an important prevalence, however, there are few treatments available in the market, so the search for molecules with pharmacological potential that can act in the same way as the disease, it is necessary considering the serious complications.
Aim:
to evaluate the possible target proteins available in the PDB database, considering the similarity with human proteins as an initial parameter and identify potential inhibitors of the chosen target using molecular docking.
Methodology:
an evaluation of the parasite proteins was carried out by means of sequence alignment and subsequently a virtual molecular coupling screening was performed with databases and computer resources available at Centro de Cómputo Avanzado de Universidad de Texas (TACC), and the best results were evaluated based on affinity, pharmacokinetics, and toxicity.
Results:
the molecular target chosen was the dUTPase. After virtual screening, 12 moles showing inhibitory potential were selected of these, 4- {3-[3- (trifluoromethyl) phenyl] isoxazole-5-yl} pyrimidine-2-amine is one of the molecules with the best profile to become a candidate in the treatment of Chagas disease.
Palavras-chave : Virtual screening; molecular docking; chagas disease; T. cruzi dUTPase.