Resumo

ARBOLEDA, John J et al. Humoral immune response induced by a commercial vaccine against vesicular stomatitis virus (VSV) in pigs. Rev Colom Cienc Pecua [online]. 2005, vol.18, n.2, pp.115-121. ISSN 0120-0690.

The goal of this study was to determine the humoral immune response induced by a previously tested bovine bivalent vaccine against the vesicular stomatitis virus in pigs. 30 female pigs were immunized with the biological product and 20 more remained as controls. We measured neutralizing antibody tittles against both serotypes of VSV, IN and NJ, in serum for all the pigs at day 0 (before inoculation) and then at 82, 182, 330, 404 days post-vaccination. Re-vaccination was performed at 434 days and again a new serum sample was tested at day 599. All the female pigs showed a similar average of background antibodies against both serotypes of VSV at day 0. At 82 days postvaccination there was a 100-fold difference between the vaccinated and unvaccinated groups in favor of the vaccinated pigs. The differences were statistically significant and remained the same through the whole experiment. Following the antigenic boost there was a new peak of NT antibodies, which was comparable to the one obtained 82 days after the first vaccination. The unvaccinated pigs only showed background levels of NT antibodies that did not change significantly along the experiment. The study shows that this is a safe and promising vaccine. This biological product induces an important immune humoral response, with potential for protection against natural VSV exposures. Future studies will show its capability to protect animals against viral challenge and prevent infection of piglets.

Palavras-chave : commercial vaccine; humoral immune response; pigs; VSV.

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