Resumo

ZUAS, Oman; MULYANA, Muhammad R  e  BUDIMAN, Harry. Analytical method validation of GC-FID for the simultaneous measurement of hydrocarbons (C₂-C₄) in their gas mixture. Rev.Colomb.Quim. [online]. 2016, vol.45, n.3, pp.22-27. ISSN 0120-2804.  https://doi.org/10.15446/rev.colomb.quim.v45n3.58085.

An accurate gas chromatography coupled to a flame ionization detector (GC-FID) method was validated for the simultaneous analysis of light hydrocarbons (C₂-C₄) in their gas mixture. The validation parameters were evaluated based on the ISO/TEC 17025 definition including method selectivity, repeatability, accuracy, linearity, limit of detection (LOD), limit of quantitation (LOQ), and ruggedness. Under the optimum analytical conditions, the analysis of a gas mixture revealed that each target component was well-separated with high selectivity property. The method was also found to be precise and accurate. The method linearity was found to be high with good correlation coefficient values (R² ≥ 0.999) for all target components. It can be concluded that the GC-FID developed method is reliable and suitable for determination of light C₂-C₄ hydrocarbons in their gas mixture. The validated method was successfully applied to the estimation of light C₂-C₄ hydrocarbons in natural gas samples, showing high performance repeatability with relative standard deviation (RSD) less than 1.0% and good selectivity with no interference from other possible components.

Palavras-chave : Method validation; hydrocarbons; GC-FID; ISO/IEC 17025.

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