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Biomédica
versão impressa ISSN 0120-4157
Resumo
RIVERA, Oriana; BENITES, Santiago; MENDIGURE, Julio e BONILLA, César Antonio. Abandonment of therapy in multidrug-resistant tuberculosis: Associated factors in a region with a high burden of the disease in Perú. Biomédica [online]. 2019, vol.39, suppl.2, pp.44-57. ISSN 0120-4157. https://doi.org/10.7705/biomedica.v39i3.4564.
Introduction:
In the context of multidrug-resistant tuberculosis, abandonment of therapy represents a serious public health problem that affects the quality of life of patients, families, and communities. Managing this phenomenon places a burden on health systems since it causes free sources of transmission in the community, thereby increasing prevalence and mortality. Thus, there is a need to study factors associated with this problem.
Objective:
This study sought to identify risk factors associated with the abandonment of therapy by patients with multidrug-resistant tuberculosis in the Peruvian region of Callao.
Materials and methods:
We conducted an analytical case-control study (cases=80; controls=180) in patients under treatment from January 1st, 2010, to December 31, 2012. Risk factors were identified using logistic regression; odds ratios (OR) and 95% confidence intervals (CI) were calculated.
Results:
The multivariate analysis identified the following risk factors: Being unaware of the disease (OR=23.10; 95% CI 3.6-36.79; p=0.002); not believing in healing (OR=117.34; 95% CI 13.57-124.6; p=0.000); not having social support (OR=19.16; 95% CI 1.32-27.77; p=0.030); considering the hours of attention to be inadequate (OR=78.13; 95% CI 4.84-125.97; p=0.002), and not receiving laboratory reports (OR=46.13; 95% CI 2.85-74.77; p=0.007).
Conclusion:
Health services must focus on the early detection of conditions that may represent risk factors to proactively implement effective, rapid and high-impact interventions.
Palavras-chave : Tuberculosis; drug resistance; risk factor.